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2018年歐盟,食品添加劑和營養(ANS)小組對羥基蒽衍生物的安全性發佈了評估報告 

原文摘要

Safety of hydroxyanthracene derivatives for use in food

EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS),

Abstract

The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a

scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily

intake that does not give rise to concerns about harmful effects to health. Hydroxyanthracene

derivatives are a class of chemical substances naturally occurring in different botanical species and

used in food to improve bowel function. The ANS Panel reviewed the available scientific data on a

possible relationship between hydroxyanthracene derivatives exposure and genotoxic and carcinogenic

effects. On the basis of the data currently available, the Panel noted that emodin, aloe-emodin and the

structurally related substance danthron have shown evidence of in vitro genotoxicity. Aloe extracts

have also been shown to be genotoxic in vitro possibly due to the presence of hydroxyanthracene

derivatives in the extract. Furthermore, aloe-emodin was shown to be genotoxic in vivo and the wholeleaf

aloe extract and the structural analogue danthron were shown to be carcinogenic. Epidemiological

data suggested an increased risk for colorectal cancer associated with the general use of laxatives, several

of which contain hydroxyanthracene derivatives. Considering the possible presence of aloe-emodin and

emodin in extracts, the Panel concluded that hydroxyanthracene derivatives should be considered as

genotoxic and carcinogenic unless there are specific data to the contrary, such as for rhein, and that

there is a safety concern for extracts containing hydroxyanthracene derivatives although uncertainty

persists. The Panel was unable to provide advice on a daily intake of hydroxyanthracene derivatives

that does not give rise to concerns about harmful effects to health.

中文整理

羥基蒽醌衍生物是一類天然存在於不同植物物種中的化學物質。

根據目前可獲得的資料,專家注意到蘆薈素、蘆薈大黃素和結構相關物質丹烷 已顯示出體外遺傳毒性的證據。

蘆薈提取物可能由於提取物中 含有羥基蒽醌衍生物而導致有遺傳毒性。

此外,蘆薈素在體內具有遺傳毒性,蘆薈提取物和結構類似物丹烷 已顯示具有致癌作用。

流行病學資料表明,一般常使用的瀉藥(其中幾種含有羥基蒽醌衍生物)與結直腸癌的風險增加有關。

考慮到提取物中可能存在蘆薈大黃素和蘆薈素,

專家組得出結論,除非有特定的相反資料,否則應將羥基蒽醌衍生物視為具有遺傳毒性和致癌作用,儘管存在不確定性。

 

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